研究実績

英語論

2024

Iida, S., Ide, S., Tamura, S., Sasai, M., Tani, T., Goto, T., Shribak, M.,Maeshima, K.(2024) Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation. Proceedings of the National Academy of Sciences 121, e2403153121.doi:10.1073/pnas.2403153121


Hibino, K., Sakai, Y., Tamura, S., Takagi, M., Minami, K., Shimazoe, M.A., Natsume, T., Kanemaki, M.T., Imamoto, N., Maeshima, K. (2024) Single-nucleosome imaging unveils that condensins and nucleosome-nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes. Nature Communications 15, 7152.doi: 10.1038/s41467-024-51454-y

 

Semeigazin, A., Iida, S., Minami, K., Tamura, S., Ide, S., Higashi, K., Toyoda, A., Kurokawa, K., Maeshima, K. (2024) Behaviors of the nucleosomes with mutant histone H4s in euchromatic domains of living human cells. Histochemistry and Cell Biology
https://link.springer.com/article/10.1007/s00418-024-02293-x


Otsuka, A., Minami, K., Higashi, K., Kawaguchi, A., Tamura, S., Ide, S., Hendzel, M.J., Kurokawa, K., Maeshima, K. (2024) Chromatin organization and behavior in RAS-transformed mouse fibroblasts.Chromosoma.https://doi.org/10.1007/s00412-024-00817-x

 

Iida, S., Ide, S., Tamura, S., Tani, T., Goto, T., Shribak, M., Maeshima, K. (2023) Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation.bioRxiv BIORXIV/2023/566679
https://doi.org/10.1101/2023.11.11.566679


2023

Maeshima, K., Iida, S., Shimazoe, M.A., Tamura, S., Ide, S. (2023) Is euchromatin really open in the cell? Trends in Cell Biology.
doi: 10.1016/j.tcb.2023.05.007

 

Smallwood, K., Watt, K. E.N.,Ide, S., Baltrunaite, K., Brunswick, C., Inskeep, K., Capannari, C., Adam, M. P., Begtrup, A., Bertola, D. R., Cho, M., Demmer, L., Demo, E., Devinsky, O., Gallagher, E. R., Sacoto, M. J. G., Jech, R., Keller-Ramey, J., Keren, B., Kussmann, J., Ladda, R., Lansdon, L. A., Lunke, S., Mardy, A., McLaughlin, H., McWalters, K., Person, R., Raiti, L., Saitoh, N., Saunders, C. J., Schnur, R., Skorvanek, M., Sell, S. L., Slavotinek, A., Sullivan, B. R., Stark, Z., Symonds, J.D., Wenger, T., Weber, S., Whalen, S., White, S. M., Willaert, R., Winkelman, J., Zech, M., Zeidler, S., Maeshima, K., Stottmann, R. W., Trainor, P. A, Weaver, K. N. (2023) Variant- and tissue-specific effects underlie phenotypic heterogeneity in individuals with heterozygous variants in POLR1A. The American Journal of Human Genetics110, 1–17.
https://doi.org/10.1016/j.ajhg.2023.03.014

 

Nozaki, T., Shinkai, S., Ide, S., Higashi, K., Tamura, S., Shimazoe, A. M., Nakagawa, M., Suzuki, Y., Okada, Y., Sasai, M., Onami, S., Kurokawa, K., Iida, S., *Maeshima, K.(2022) Condensed but liquid-like domain organization of active chromatin regions in living human cells. Science Advances. 9, eadf1488 Doi: 10.1126/sciadv.adf1488
https://www.science.org/doi/10.1126/sciadv.adf1488

 

2022

Minami, K., Iida, S., Maeshima, K. (2022) Chromatin organization and DNA damage. The Enzymes Volume LI: DNA damage and double strand breaks (Eds. K. Yoshikawa and F. Tamanoi). Chapter 3. Academic Press/Elsevier.
https://doi.org/10.1016/bs.enz.2022.08.003
フリーリンク(11月16日まで)


Maeshima, K., Meshorer, E. (2022) Editorial Overview: Emerging concepts and tools in genome organization and chromatin function in eukaryotes
Current Opinion in Cell Biology, 78, 102120
https://doi.org/10.1016/j.ceb.2022.102120

Maeshima, K.(2022) A phase transition for chromosome transmission when cells divide. Nature.609, 35-36.
https://doi.org/10.1038/d41586-022-01925-3


Ide, S., Tamura, S., Maeshima, K. (2022) Chromatin behavior in living cells: lessons from single-nucleosome imaging and tracking. BioEssays. 44, 2200043.
doi: 10.1002/bies.202200043


Iida, S., Shinkai, S.,Itoh, Y., Tamura, S., Kanemaki, M.T., Onami, S., Maeshima, K. (2022) Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells. Science Advances. 8, eabn5626
doi: 10.1126/sciadv.abn5626


2021

Hansen, J.C., Maeshima, K., Hendzel, M.J. (2021) The solid and liquid states of chromatin. Epigenetics & Chromatin. 14, 50.
doi: 10.1186/s13072-021-00424-5


Ide, S., Sasaki, A., Kawamoto, Y., Bando, T., Sugiyama, H., Maeshima, K.(2021) Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs. Epigenetics & Chromatin. 14, 46.
doi: 10.1186/s13072-021-00421-8


Maeshima, K., Iida, S. (2021) Loopy world of cohesin eLife 10, e71585.
doi: 10.7554/eLife.71585

 

Itoh, Y., Woods, E.J.,Minami, K., *Maeshima, K., *Collepardo-Guevara, R.(2021) Liquid-like chromatin in the cell: What can we learn from imaging and computational modeling? Current Opinion in Structural Biology.71, 123–135
doi: 10.1016/j.sbi.2021.06.004

Hoencamp, C., Dudchenko, O., Elbatsh, A. M.O., Brahmachari, S., Raaijmakers, J. A., van Schaik, T., Cacciatore, Á. S., Contessoto, V., van Heesbeen, R. G.H.P., van den Broek, B., Mhaskar, A. N., Teunissen, H., St Hilaire, B. G., Weisz, D., Omer, A. D., Pham, M., Colaric, Z., Yang, Z., Rao, S. S.P., Mitra, N., Lui, C., Yao, W., Khan, R., Moroz, L. L., Kohn, A., St. Leger, J., Mena, A., Holcroft, K., Gambetta, M. C., Lim, F., Farley, E., Stein, N., Haddad, A., Chauss, D., Mutlu, A. S., Wang, M. C., Young, N. D., Hildebrandt, E., Cheng, H. H., Knight, C. J., Burnham, T. L.U., Hovel, K. A., Beel, A. J., Mattei, P.-J., Kornberg, R. D., Warren, W. C., Cary, G., Gómez-Skarmeta, J. L., Hinman, V., Lindblad-Toh, K., di Palma, F., Maeshima, K., Multani, A. S., Pathak, S., Nel-Themaat, L., Behringer, R. R., Kaur, P., Medema, R. H., van Steensel, B., de Wit, E., Onuchic, J. N., Di Pierro, M., Lieberman-Aiden, E., Rowland, B. D. (2021) 3D genomics across the tree of life reveals condensin II as a determinant of architecture type. Science 372, 984-989.
https://science.sciencemag.org/content/372/6545/984
doi:10.1126/science.abe2218

 


Maeshima, K.(2021) New door to understanding transcription, open with caution. In “Voices”,Molecular Cell, 81, 1581-1582
https://doi.org/ 10.1016/j.molcel.2021.03.046

 

Maeshima, K., Iida, S., Tamura, S. (2021) Physical nature of chromatin in the nucleus.
Cold Spring Harbor Perspectives in Biology. a040675.
doi:10.1101/cshperpsect.a040675
Cover Images

 

Itoh, Y., Iida, S., Tamura, S., Nagashima, R., Shiraki, K., Goto, T., Hibino, K., Ide, S., Maeshima, K. (2021) 1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells. Life Science Alliance. 4, e20200100
https://www.life-science-alliance.org/content/4/4/e202001005

 

2020

Ide, T., Ochi, H., Imai, R., Maeshima, K. (2020) Transcriptional suppression of ribosomal DNA with phase separation. Science Advances. 6, eabb5953

Matsuyama, S., Maeshima, K., Shimura, M. (2020) Imaging intracellular elements and structure by synchrotron X-ray with focusing system. Journal of Analytical Atomic Spectrometry. 35, 1279-1294.
https://doi.org/10.1039/D0JA00128G

Maeshima, K., Tamura, S., Hansen, J.C., Itoh, Y. (2020) Fluid-like chromatin: toward understanding the real chromatin organization present in the cell.
Current Opinion in Cell Biology. 64, 77-89.
https://doi.org/10.1016/j.ceb.2020.02.016

Ashwin, S.S., Maeshima, K., Sasai, M. (2020) Heterogeneous fluid-like movements of chromatin and their implications to transcription.Biophysical Reviews. 12, 461–468.
DOI: 10.1007/s12551-020-00675-8

Babokhov, M., Hibino, K., Ito, Y., Maeshima, K. (2020) Local chromatin motion and transcription. Journal of Molecular Biology. 432, 694-700.
https://doi.org/10.1016/j.jmb.2019.10.018


2019

Marie Anne O’Donnell (2019) Kazuhiro Maeshima : Excitement under the microscope (Interviewed by JCB as "People & Ideas”)
Journal of Cell Biology 218, 3529–3530.
Doi: https://doi.org/10.1083/jcb.201910088

Ashwin, S.S., Nozaki, T., Maeshima, K., Sasai, M. (2019) Organization of fast and slow chromatin revealed by single-nucleosome dynamics.
Proc Natl Acad Sci USA. 116, 19939-19944
https://doi.org/10.1073/pnas.1907342116

 

Prieto, E.I., Maeshima, K. (2019) Dynamic chromatin organization in the cell. Essays in Biochemistry. 63, 133-145.
doi: 10.1042/EBC20180054


Maeshima, K., Ide, S., Babokhov, M. (2019) Dynamic chromatin organization without the 30-nm fiber. Current Opinion in Cell Biology. 58, 95–104
doi: 10.1016/j.ceb.2019.02.003


Nagashima, R., Hibino, K., Ashwin, S.S., Babokhov, M., Fujishiro, S., Imai, R., Nozaki, T., Tamura, S., Tani, T., Kimura, H., Shribak, M., Kanemaki, M.T., Sasai, M., Maeshima, K. (2019) Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II. Journal of Cell Biology. 218, 1511-1530.
doi: 10.1083/jcb.201811090

Spotlight論文

2018

Kazuhiro Maeshima(2018) How small numbers of long genomic DNA are stored in cells. Minorities and Small Numbers from Molecules to Organisms in Biology (Editors Takeharu Nagai and Yuichi Togashi), Springer Nature Singapore Pte Ltd.. Chapter 8, 53-58.
https://doi.org/10.1007/978-981-13-2083-5_8

Maeshima, K., Tamura, S., Shimamoto, Y. (2018) Chromatin as a nuclear spring. Biophysics and Physicobiology. 15, 189-195.
doi: 10.2142/biophysico.15.0_189
https://www.jstage.jst.go.jp/article/biophysico/15/0/15_189/_article/-char/en


Maeshima, K., Hibino, K., Hudson, D.F. (2018) Condensins under the microscope. Journal of Cell Biology. 217, 2229–2231
doi: 10.1083/jcb.201804078

Maeshima, K., Matsuda, T., Shindo, Y., Imamura, H., Tamura, S., Imai, R., Kawakami, S., Nagashima, R., Soga, T., Noji, H., Oka, K., Nagai, T. (2018) A transient rise in free Mg2+ ions coupled with ATP reduction promotes mitotic chromosome condensation. Current Biology.28, 444–451
https://www.sciencedirect.com/science/article/pii/S0960982217316688

Dispatch論文

Hansen, J.C., Connolly, M., McDonald, C.J., Pan, A., Pryamkova, A., Ray, K., Seidel, E., Tamura,S., Rogge, R., Maeshima, K. (2018) The 10-nm Chromatin Fiber and its Relationship to Interphase Chromosome Organization.
Biochemical Society Transactions. 46, 67-76
DOI: 10.1042/BST20170101

2017

Nozaki, T., Hudson, F. D., Tamura, S., Maeshima, K. (2017) Dynamic chromatin folding in the cell. Nuclear Architecture and Dynamics(Editors Christophe Lavelle and Jean-Marc Victor). Chapter 4, 101-122
https://doi.org/10.1016/B978-0-12-803480-4.00004-1

Imai, R., Nozaki, T., Tani, T., Kaizu, K., Hibino, K., Ide, S., Tamura, S., Takahashi, K., Shribak, M., and Maeshima, K. (2017) Density imaging of heterochromatin in live cells using orientation-independent-DIC microscopy.
Molecular Biology of the Cell. 28, 3349-3359
http://www.molbiolcell.org/content/28/23/3349.full


Nozaki, T., Imai, R., Tanbo, M., Nagashima, R., Tamura, S., Tani, T., Joti, Y., Tomita, M., Hibino, K., Wendt, K.S., Okada, Y., Nagai, T., Maeshima, K. (2017) Dynamic organization of chromatin domains revealed by super-resolution live-cell imaging. Molecular Cell. 67, 282-293
http://dx.doi.org/10.1016/j.molcel.2017.06.018

 

Shimamoto, Y., Tamura, S., Masumoto, H., Maeshima, K. (2017) Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity. Molecular Biology of the Cell28, 1580-1589
http://www.molbiolcell.org/content/28/11/1580.full

Shinkai, S., Nozaki, T., Maeshima, K., Togashi, Y. (2017) Bridging the dynamics and organization of chromatin domains by mathematical modeling. Nucleus
http://dx.doi.org/10.1080/19491034.2017.1313937

Hibino, K., Kaizu, K., Takahashi, K., Maeshima, K. (2017) Combination approach of live-cell imaging and computational modeling toward further comprehensive understanding genome, chromatin and epigenetics. Epigenetics and Systems Biology (Editor Leonie Ringrose) Chapter 11, 225-238.
Doi.org/10.1016/B978-0-12-803075-2.00011-8


2016

Shinkai, S., Nozaki, T., Maeshima, K., Togashi, Y. (2016) Dynamic nucleosome movement tells Structural information of topological chromatin domains in human cells. PLOS Computational Biology 12, e1005136.
Doi: 10.1371/ journal.pcbi.1005136
カバーイメージ

 

Kawamoto, Y., Sasaki, A., Chandrana, A., Hashiya, K., Ide, S., Bando, T., Maeshima, K., Sugiyama, H. (2016) Targeting 24 bp within Telomere Repeat Sequences with Tandem Tetramer Pyrrole– Imidazole Polyamide Probes.
Journal of the American Chemical Society 138, 14100-14107.
Doi: 10.1021/jacs.6b09023

Chen, C., Hwa Lim, H., Shi, J., Tamura, S., Maeshima, K., Surana, U., and Gan, L. (2016) Budding yeast chromatin is dispersed in a crowded nucleoplasm. Molecular Biology of the Cell 27, 3357-3368.
Doi: 10.1091/mbc.E16-07-0506

Sasaki, A., Ide, S., Kawamoto, Y., Bando, T., Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K. (2016) Telomere Visualization in Tissue Sections Using Pyrrole-Imidazole Polyamide Probes. Scientific Reports 6, 2926.
Doi: 10.1038/srep29261

 

Imai, R., Komeda, S., Shimura, M., Tamura, S., Matsuyama, S., Nishimura, K., Rogge, R., Matsunaga, A., Hiratani, I., Takata, H., Uemura, M., Iida, Y., Yoshikawa, Y., Hansen, JC., Yamauchi, K., Kanemaki, MT, Maeshima, K. (2016) Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex. Scientific Reports 6, 24712.
Doi: 10.1038/srep24712

 

Maeshima, K., Rogge, R., Tamura, S., Joti, Y., Hikima, T., Szerlong, H., Krause, C., Herman, J., DeLuca, J., Ishikawa, T., Hansen, J.C. (2016) Nucleosomal arrays self-assemble into supramolecular globular structures lacking 30-nm fibers. EMBO J. 35, 1013-1149.
Doi: 10.15252/embj.201592660

 

Maeshima, K., Ide, S., Hibino, K., Sasai, M. (2016) Liquid-like behavior of chromatin.
Current Opinion in Genetics and Development 37, 36–45. 
Doi: 10.1016/j.gde.2015.11.006

 

2015

Liang, Z., Zickler, D., Prentiss, M., Chang. F.S., Witz, G., Maeshima, K., Kleckner, N. (2015) Chromosomes progress to metaphase in multiple discrete steps via global compaction/expansion (stress) cycles. Cell 161, 1124–1137.
http://dx.doi.org/10.1016/j.cell.2015.04.030

 

Kawamoto, Y., Sasaki, A., Hashiya, K., Ide, S., Bando, T., Maeshima, K., Sugiyama, H. (2015) Tandem trimer pyrrole-imidazole polyamide probes targetting 18base pairs in human telomere sequences. Chemical Science 6, 2307-2312.
Doi: 10.1039/c4sc03755c

 

Maeshima, K. Kaizu, K., Tamura, S., Nozaki, T., Kokubo, T., Takahashi, K. (2015) The physical size of transcription factors is key to transcriptional regulation in the chromatin domains. Journal of Physics: condensed matter 27, 064116 (10pp).
Doi: 10.1088/0953-8984/27/6/064116
Lab Talk

 

2014

Maeshima, K., Nishino, Y., Joti, Y. (2014) Irregular organization in the human chromosomes revealed by X-ray scattering. SPring-8 Research Frontiers 2013 32-33.
Pfd

Maeshima, K., Imai, R., Hikima, T., Joti, Y. (2014) Chromatin Structures Revealed by Small-angle Xray Scattering Analysis and Computational Modeling. Methods 70, 154-161.
Doi:10.1016/j.ymeth.2014.08.008

Hirata, A., Nokihara, K., Kawamoto, Y., Bando, T., Sasaki, A., Ide ,S., Maeshima, K., Kasama, T., Sugiyama, H. (2014) Structual Evaluation of Tandem, Hairpin Pyrrole-Imidazole Polyamides Recognizing Human Telomeres. Jouanal of American Chemical Society 136, 11546-11554.
Doi: 10.1021/ja506058e

 

Maeshima, K., Imai, R.,Tamura, S., Nozaki,T. (2014) Chromatin as dynamic 10-nm fibers. Chromosoma 123, 225-237.
Doi: 10.1007/s00412-014-0460-2

Nozaki, T., Imai, R., Tamura, S., Maeshima, K. (2014) Single nucleosome imaging in living human cells (Technical note,cover image). Cytologia 79 (1) 1-2.
Doi: 10.1508/cytologia.79.1.1

Kuga, T., Nie, H., Kazami, T., Satoh, M., Matsushita, K., Nomura, F., Maeshima, K., Nakayama, Y., Tomonaga, T. (2014) Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation. Oncogenesis 3, e9.4
Doi: 10.1038/oncsis.2014.6


Maeshima, K., Funakoshi, T., Imamoto, N. (2014) Cell-fusion method to visualize interphase nuclear pore (NPC) formation.Methods in Cell Biology 122, 239-254.

2013

Kawamoto, Y., Bando, T., Kamada, F., Li, Y., Hashiya, K., Maeshima, K., Sugiyama, H. (2013) Development of a New Method for Synthesis of Tandem Hairpin Pyrrole-Imidazole Polyamide Probes Targeting Human Telomeres. Journal of the American Chemical Society 135, 16468-16477.
Doi: 10.1021/ja406737n

 

Takata, H., Hanafusa, T., Mori, T., Shimura, M., Iida,Y., Ishikawa, K., Yoshikawa, K., Yoshikawa, Y., Maeshima, K. (2013) Chromatin compaction protects genomic DNA from radiation damage. PLOS ONE 8, e75622.
Doi: 10.1371/journal.pone.0075622

 

Nozaki, T., Kaizu, K., Pack, C.G., Tamura, S., Tani, T., Hihara, S., Nagai, T., Takahashi, K., Maeshima, K. (2013) Flexible and dynamic nucleosome fiber in living mammalian cells. Nucleus 4, 349-356.
Doi: 10.4161/nucl.26053.

Shang, W. H., Hori, T., Martins, N. M., Toyoda, A., Misu, S., Monma, N., Hiratani, I., Maeshima, K., Ikeo, K., Fujiyama, A., Kimura, H., Earnshaw, W.C., Fukagawa, T., (2013) Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres. Dev Cell 24, 635-648.

Takata, H., Matsunaga, S., Maeshima, K. (2013) The organisation of genomic DNA in mitotic chromosomes: a novel view. In Greilhuber, J., Leitch, I., Wendel, J., Dolezel, J.(Eds.), Plant Genome Diversity 2, (pp: 33-34), Springer Verlag, Germany

2012

Hihara, S., Pack, C. G., Kaizu, K., Tani, T., Hanafusa, T., Nozaki, T., Takemoto, S., Yoshimi, T., Yokota, H., Imamoto, N., Sako, Y., Kinjo, M., Takahashi, K., Nagai, T., Maeshima, K. (2012) Local Nucleosome Dynamics Facilitate Chromatin Accessibility in Living Mammalian Cells.
Cell Reports 2, 1645-1656 .
Web

 

Joti, Y., Hikima, T., Nishino, Y., Kamada F., Hihara S., Takata H., Ishikawa, T., Maeshima, K. (2012) Chromosomes without a 30-nm chromatin fiber. Nucleus 3, 404-410.
pdf

 

Takata, H., Nishijima, H., Maeshima, K., Shibahara, K. (2012) The integrator complex is required for integrity of Cajal bodies. J Cell Sci. 125, 166-175.
pdf

 

Nishino, Y., Eltsov, M., Joti, Y., Ito, K.,Takata, H., Takahashi, Y., Hihara, S., Frangakis, A.S., Imamoto, N., Ishikawa, T., Maeshima, K. (2012) Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure. EMBO J. 31, 1644-53.
pdf

 

2011

Takata, H., Maeshima, K. (2011) Irregular folding of nucleosomes in the cell: comment on "Cracking the chromatin code: precise rule of nucleosome positioning" by Edward N. Trifonov. Phys Life Rev 8, 51-52; discussion 69-72.
pdf

Maeshima, K., Iino, H., Hihara, S., Imamoto, N. (2011) Nuclear size, nuclear pore number and cell cycle. Nucleus 2, 113-118.
pdf

2010

Maeshima, K., Hihara, S., Takata, H. (2010 (published in 2011) New insight into the mitotic chromosome structure: irregular folding of nucleosome fibers without 30-nm chromatin structure. Cold Spring Harb Symp Quant Biol 75, 439-444.
pdf

 

Maeshima, K., Iino, H., Hihara, S., Funakoshi, T., Watanabe, A., Nishimura, M., Nakatomi, R., Yahata, K., Imamoto, F., Hashikawa, T., et al. (2010) Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase. Nat Struct Mol Biol 17, 1065-1071
pdf

 

Matsuyama, S., Shimura, M., Fujii, M., Maeshima, K., Yumoto, H., Mimura, H., Sano, Y., Yabashi, M., Nishino, Y., Tamasaku, K., et al. (2010) Elemental mapping of frozen hydrated cells with cryo-scanning X-ray fluorescence microscopy. X-Ray Spectrometry 39, 260-266.
pdf

Iino, H., Maeshima, K., Nakatomi, R., Kose, S., Hashikawa, T., Tachibana, T., Imamoto, N. (2010) Live imaging system for visualizing nuclear pore complex (NPC) formation during interphase in mammalian cells. Genes Cells 15, 647-660.
pdf

Maeshima, K., Hihara, S., Eltsov, M. (2010) Chromatin structure: does the 30-nm fibre exist in vivo? Curr Opin Cell Biol. 22, 291-297.
pdf

 

2009

Takemoto, A., Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., Imamoto, N., Yokoyama, S., Hirano, T., Watanabe, Y., et al. (2009) The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Nat Struct Mol Biol. 16, 1302-1308.
pdf

 

Nishino, Y., Takahashi, Y., Imamoto, N., Ishikawa, T., Maeshima, K. (2009) Three-dimensional visualization of a human chromosome using coherent X-ray diffraction. Phys Rev Lett. 102, 018101.
pdf

2008

Tahara, K., Takagi, M., Ohsugi, M., Sone, T., Nishiumi, F., Maeshima, K., Horiuchi, Y., Tokai-Nishizumi, N., Imamoto, F., Yamamoto, T., et al. (2008) Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol. 180, 493-506.
pdf

Eltsov, M., Maclellan, K. M., Maeshima, K., Frangakis, A. S., and Dubochet, J. (2008) Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ. Proc Natl Acad Sci USA 105, 19732-19737.
pdf

Iwai, Y., Ikeda, T., Kojima, T. M., Yamazaki, Y., Maeshima, K., Imamoto, N., Kobayashi, T., Nebiki, T., Narusawa, T., and Pokhil, G.-P. (2008) Ion irradiation in liquid of μm3 region for cell surgery. Applied Physics Letters 92, 23509 (23503 pages).Iwai, Y., Ikeda, T., Kojima, T. M., Yamazaki, Y., Maeshima, K., Imamoto, N., Kobayashi, T., Nebiki, T., Narusawa, T., and Pokhil, G.-P. (2008) Ion irradiation in liquid of μm3 region for cell surgery. Applied Physics Letters 92, 23509 (23503 pages).
pdf

Maeshima, K., Eltsov, M. (2008) Packaging the genome : the structure of mitotic chromosomes. J Biochem. 143, 145-53.Maeshima, K., Eltsov, M. (2008) Packaging the genome : the structure of mitotic chromosomes. J Biochem. 143, 145-53.
pdf

Wendt, K.S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., et al. (2008) Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature 451, 796-801.
pdf

2007

Funakoshi, T., Maeshima, K., Yahata, K., Sugano, S., Imamoto, F., Imamoto, N. (2007) Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes. FEBS Lett. 581, 4910-4916.
web

Yahata, K., Maeshima, K., Sone, T., Ando, T., Okabe, M., Imamoto, N., Imamoto, F. (2007) cHS4 insulator-mediated alleviation of promoter interference during cell-based expression of tandemly associated transgenes. J Mol Biol. 374, 580-590.
web

2006

Maeshima, K., Yahata, K., Sasaki, Y., Nakatomi, R., Tachibana, T., Hashikawa, T., Imamoto, F., Imamoto, N. (2006) Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J Cell Sci. 119, 4442-4451.
web

2005

Maeshima, K., Eltsov, M., Laemmli, U. K. (2005) Chromosome structure: improved immunolabeling for electron microscopy. Chromosoma 114, 365-375.
pdf

2003

Maeshima, K., Laemmli, U. K. (2003) A two-step scaffolding model for mitotic chromosome assembly. Dev Cell 4, 467-480.
pdf

2001

Maeshima, K., Janssen, S., Laemmli, U.K. (2001) Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides. EMBO J. 20, 3218-3228.
pdf

このページのトップへ

日本語総説

井手 聖、前島 一博「相分離モデルで理解する転写制御〜核小体と転写コンデンセート〜」「生体の科学」 74巻3号 2023 pp.234-239
DOI https://doi.org/10.11477/mf.2425201681

飯田史織、前島一博「生きた細胞のなかのヌクレオソームの動きをみる」
現代化学 東京化学同人 3月号 51-53, 2022.

飯田史織、前島一博「核内クロマチンの物理的な性質」月刊「細胞」2022年10月号特集「DNAの物性から理解するゲノムモダリティ」54, 12-15, 2022.

井手 聖、前島一博「核内構造体と液―液相分離 〜核小体と転写コンデンセートを中心に〜」生化学 94, 485-493, 2022.
doi:10.14952/SEIKAGAKU.2022.940485

島添將誠、井手聖、前島一博
「物性から迫るクロマチンの実像-相分離するクロマチンは液体か固体か?-」
実験医学 (増刊 セントラルドクマの新常識) 羊土社 40, 32-41, 2022
https://www.yodosha.co.jp/jikkenigaku/book/9784758104043/index.html

伊藤優志,井手聖, 前島一博「ヘキサンジオールは細胞内のクロマチンを凝縮させる」 生物物理 61, 385-388, 2021 doi: 10.2142/biophys.61.385

前島一博「生物物理学会とクロマチン」生物物理 2021年 61, 211ページ
doi: 10.2142/biophys.61.211

島本勇太、前島一博「ラミンとクロマチンの連携による核構造の維持メカニズム(Nuclear integrity maintenance by lamin and chromatin)」医学のあゆみ 2020年 272, 2, 157-161ページ

前島一博、松田知己、永井健治 「蛍光マグネシウムイオンプローブの開発とそれを利用した新たな染色体凝縮メカニズムの解明」マグネシウム(Journal of Japanese society for Magnesium Research)2019年 37, 13-18ページ

佐藤か奈、日比野佳代、前島一博「遺伝子が転写されるときのヌクレオソームの”動き”を捉えた!」academist Journal. 2019年5月

井手 聖、永島崚甫、前島一博「クロマチンダイナミクス〜クロマチンの物理的特性とその生物学的意味〜」実験医学増刊「染色体の新常識」36巻, 80-86ページ. 羊土社2018年11月

島本勇太、田村佐知子、前島一博「DNA は細胞のバネとしても働いている」生物物理、2018年 生物物理 58, 24-26ページ

日比野佳代・前島一博「少数支配を実現するゲノム―驚異のDNA収納術―」 実験医学、羊土社、2017年12月号 3211-3217ページ

野崎慎・前島一博「生細胞の超解像イメージングにより明らかにされたクロマチンドメインのダイナミックな構造」 ライフサイエンス新着論文レビュー 2017年8月

前島一博「1章 クロマチンの構造と染色体」 遺伝子発現制御機構(田村隆明・浦聖恵編集) 7-15 ページ、東京化学同人、2017 年 3 月

前島一博「少数のゲノムDNAが細胞の中に収納される仕組み」「少数性生物学の世界」第8章 61-68 ページ、 日本評論社、2017 年 3 月

前島一博「細胞内ゲノムDNAの折り畳み構造」科研費NEWS Vol. 3 14ページ「最近の研究成果トピックス」日本学術振興会、2016 年 12 月

日比野佳代、前島一博「一分子計測で探るクロマチンダイナミクス」うちのとくいわざ、日本免疫学会JSI Newsletter (2016) 24巻, 24ページ

前島 一博 「柔軟に収納されている生命の設計図」共済だよりレター、日本私立学校振興・共催事業団 発行 (2014) 11月号 14ページ

前島 一博 「教科書の染色体構造が変わる?!」 『はっきりわかる現代サイエンスの常識辞典』成美堂出版 2014年9月5日 80-81ページ

前島 一博 「DNAはなぜねじれているのですか?」子供の科学(2014) 8月号.46ページ。

前島 一博「DNA収納のなぞ:DNAは細胞内でどのように折りたたまれているのか?」「遺伝子が語る生命 38億年の謎ーなぜ、ゾウはネズミより長生きか?」悠書館2014年6月27日134-144ページ。

今井亮輔、海津一成、野崎 慎、前島一博、高橋恒一「定量的1分子蛍光イメージングと計算機シミュレーションを用いたゲノムダイナミクスの解析」、生化学(2014)86巻2号、192-200ページ

高田英昭、前島一博「ゲノムDNAの凝縮が放射線耐性をうみだす」日本アイソトープ協会広報誌「Isotope News」2014年 3月号 2-6ページ

前島一博「不規則な収納が生む自由-DNA収納の基本を問い直す-」「変わる」
生命誌年刊号 (2014) 111-117

前島一博「遺伝子を顕微鏡で見る」「遺伝子図鑑」(2013)226-227

前島一博「放射光によるヒト染色体の構造解析」放射光(2013)26巻4号(7月号) 206-213

野崎慎、前島一博「30nmクロマチン線維は存在しない!」化学と生物 (2013) 51, 177-182


前島一博、城地保昌、西野吉則、,高田英昭、鎌田福美、日原さえら「ヒトゲノムDNAの不規則で柔軟な収納原理」生物物理(2013) 53, 4-10

日原さえら , 前島一博「分裂期染色体の構築原理」実験医学(2009) 27 2723-2731

前島一博 , 西野吉則「コヒーレントX線回折によるヒト染色体構造の3次元観察」生物物理(2009) 49 298-300

前島一博 「染色体の内部構造を見る」細胞工学別冊「電子顕微鏡で読み解く生命のなぞ(ナノワールドに迫るパワフル技術入門)(2008) 121-129

前島一博、吉田圭介、白髭克彦「姉妹染色体間の接着因子、コヒーシンの新たな機能」蛋白質核酸酵素 (2008) 53, 1337-1344

前島一博、今本尚子「細胞周期における核膜孔のダイナミクス」生化学 (2008) 2月号, 118-124

前島一博,矢幡一英,今本文男,今本尚子「インスレーター/バウンダリー配列を用いた複数の導入遺伝子を安定的に発現させるシステム 」羊土社バイオテクノロジージャーナル(2007)9-10月号,557-563 

前島一博 「染色体の凝縮メカニズム」細胞工学 (2006) 25, 486?491.

前島一博 「染色体:生命を担う驚異の構造」蛋白質核酸酵素 (2005) 50, 1620-1629.

今本文男、曽根岳史、矢幡一英、佐々木ゆかり、高木昌俊、前島一博、今本尚子、「生細胞への複数種cDNAの共導入と発現量の制御」蛋白質核酸酵素(2005) 50, 1637-1648

このページのトップへ